The Circular City + Living Systems Lab (CCLS) is an interdisciplinary group of faculty and students applying principles of research and design to investigate transformative strategies for future cities that are adaptive and resilient while facing climate change. Synthesizing expertise from architecture, landscape architecture, engineering, planning, biology, and ecology, the lab’s innovative research spans core topics such as the integration of living systems in the built environment to produce and circulate resources within the food-water-energy nexus, and spatial design responses to COVID-19. Ongoing work at the CCLS includes research on urban integration of aquaponics, urban and building-integrated agriculture, circular economies in the food industry, algae production, and green roof performance.